Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management
نویسندگان
چکیده
منابع مشابه
STUDY ON THE HEPATOTOXICITY OF ANTI-TUBERCULOSIS DRUGS IN 190 PATIE NTS WITH PULMONARY AND E XTRAPULMONARY TUBERCULOSIS
Tuberculosis is one of the oldest diseases that affects humans. The cause of this disease is Mycobacterium tuberculosis. This disease affects approximately 8.8 million people worldwide and led to over 3 million deaths in 1995. 95% of those affected and 98% of deaths occurred in developing countries. Hepatic reactions constitute a major proportion of drug reactions to antituberculosis drugs ...
متن کاملAnti-Tuberculosis Drug-Induced Hepatotoxicity: A Review
Hepatotoxicity, a serious adverse drug reaction in tuberculosis (TB) patients receiving anti-TB drugs, is one of the most challenging clinical problems worldwide. Despite increasing awareness of clinicians and public, even now it remains an enormous problem and causes of hospitalization and life-threatening events. Considering the importance of anti-TB drug-induced hepatotoxicity (DIH) as a maj...
متن کاملDrug-induced Hepatotoxicity of Anti-tuberculosis Drugs and Their Serum Levels
The correlation between serum anti-tuberculosis (TB) drug levels and the drug-induced hepatotoxicity (DIH) remains unclear. The purpose of this study was to investigate whether anti-TB DIH is associated with basal serum drug levels. Serum peak levels of isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), and ethambutol (EMB) were analyzed in blood samples 2 hr after the administration of ant...
متن کاملstudy on the hepatotoxicity of anti-tuberculosis drugs in 190 patie nts with pulmonary and e xtrapulmonary tuberculosis
tuberculosis is one of the oldest diseases that affects humans. the cause of this disease is mycobacterium tuberculosis. this disease affects approximately 8.8 million people worldwide and led to over 3 million deaths in 1995. 95% of those affected and 98% of deaths occurred in developing countries. hepatic reactions constitute a major proportion of drug reactions to antituberculosis drugs bein...
متن کاملManagement of and risk factors related to hepatotoxicity during tuberculosis treatment.
INTRODUCTION Hepatotoxicity is one of the most frequent adverse events occurring during tuberculosis treatment that may negatively affect treatment compliance, clinical outcome. This study was designed to evaluate management, risk factors related to hepatotoxicity during tuberculosis treatment. PATIENTS AND METHODS Hospitalized patients for tuberculosis treatment at Sureyyapasa Chest Diseases...
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ژورنال
عنوان ژورنال: Journal of Clinical and Experimental Hepatology
سال: 2013
ISSN: 0973-6883
DOI: 10.1016/j.jceh.2012.12.001